Dr. Kazuhiko Adachi
Dr. Adachi studies protein-protein and protein-DNA interactions, which have an effect on biological functions such as sickle hemoglobin polymerization and a process of forming functional hemoglobin in vivo. He also investigates quality control of misfolded and unstable unbalanced globin chains in vivo that can lead to red blood cell destruction including the mechanisms of ubiquitin-mediated nascent and unstable unassociated globin chain degradation and role of chaperones. Dr. Adachi’s long-range goal is to define molecular strategies to cure sickle cell disease and thalassemia syndrome. He is currently designing hemoglobin variants and peptides for possible use in gene therapy for these diseases and is also working on blood substitutes. In addition, he is using a computerized screening strategy to identify inhibitors of the polymerization of sickle hemoglobin in an attempt to develop a therapeutic approach to sickle cell disease. He employs biochemical, biophysical and recombinant DNA technologies. In particular, his work involves various spectroscopy methods, x-ray analysis, kinetics of polymerization and assembly of recombinant hemoglobins, yeast and bacterial expression systems as well as cell-free systems and site-directed mutagenesis.