Luca Melchiori, PhD

Group Leader

I joined Stefano’s lab in March 2007 to carry on my PhD program. My are of interest has always been in hematology and development of the hematopoietic system. During my time with Stefano I had the opportunity to investigate the mechanisms of abnormal erythropoiesis in beta-thalassemia, enjoying a very vibrant environment and cutting edge facilities. After completion of my PhD in 2010 I moved to University of Oxford where my research focused on mechanisms of lineage commitment of hematopoietic stem cells, especially commitment toward the T cell lineage. In 2012 I joined a biotech called Adaptimmune, which is focusing of developing specific peptide enhanced affinity receptors (SPEAR® T-cells) for adoptive cell therapy in cancer. As of now I am a Group Leader of the T Cell Correlates Group in the Translational Sciences division, directing a team of four people. The goal of my team is to find signatures of response and side effects in SPEAR-T cell product together with better understand the mechanisms of action of the T cell during tumour eradication.